The Football Association of Wales had asked UEFA to change their rules and allow the exile clubs into the Europa League via the Welsh Cup if they opted out of the FA Cup but the request was turned down at a meeting of the governing body's executive committee in Istanbul.
FAW chief executive Jonathan Ford told Press Association Sport he was "bitterly disappointed" by the decision.
Wales also lost out to the Czech Republic in their bid to host the 2015 European Under-21 Championships.
Source: PA
Source: PA